88899-55-2
622.8
C35H58O9
Soluble in ethanol or methanol: 0.1 mg/ml; in DMSO: 5 mg/ml. Poor water solubility.
-20°C
Bafilomycin A1 is a potent and selective inhibitor of the vacuolar-type H+-ATPase (V-ATPase), an enzyme responsible for maintaining acidic pH in cellular compartments such as lysosomes and endosomes.
In the life science field, Bafilomycin A1 is primarily used as a research tool to investigate the role of V-ATPase and lysosomal acidification in various cellular processes. By inhibiting V-ATPase, Bafilomycin A1 disrupts the acidification of cellular compartments, which in turn affects processes such as protein degradation, autophagy, endocytosis, and vesicular trafficking.
Bafilomycin A1 can be used to study autophagy, a cellular process involved in the degradation and recycling of cellular components. By inhibiting V-ATPase, Bafilomycin A1 blocks the final step of autophagy, preventing the fusion of autophagosomes with lysosomes and thereby inhibiting autophagic degradation.
0 lbs
1.25 x 1.75 x 1.25
Research or further manufacturing use only, not for food or drug use.
